Frequently Asked Questions

Yes, clinical depression is a serious, but treatable, mental illness. It is a medical condition, not a personal weakness.
Clinical depression is a serious condition that negatively affects how a person thinks, feels, and behaves. In contrast to normal sadness, clinical depression is persistent, often interferes with a person’s ability to experience or anticipate pleasure, and significantly interferes with functioning in daily life. Untreated, symptoms can last for weeks, months, or years; and if inadequately treated, depression can lead to significant impairment, other health-related issues, and in rare cases, suicide.
The first step to being diagnosed is to visit a doctor for a medical evaluation. Certain medications, and some medical conditions such as thyroid disorder, can cause similar symptoms as depression. A doctor can rule out these possibilities by conducting a physical examination, interview and lab tests. If the doctor eliminates a medical condition as a cause, he or she can implement treatment or refer the patient to a mental health professional.
Depression is twice as common among women as among men. About 20 percent of women will experience at least one episode of depression across their lifetime. Scientists are examining many potential causes for and contributing factors to women’s increased risk for depression. Biological, life cycle, hormonal and psychosocial factors unique to women may be linked to women’s higher depression rates. Researchers have shown, for example, that hormones affect brain chemistry, impacting emotions and mood.
Most people who suffer from depression do not attempt suicide, but according to Mental Health America, 30%-70% of suicide victims have suffered from some form of depression. This figure demonstrates the importance of seeking professional treatment for yourself or someone you love if you suspect depression.
No. Lack of sleep alone cannot cause depression, but it does play a role. Lack of sleep resulting from another medical illness or the presence of personal problems can intensify depression. Chronic inability to sleep is also an important clue that someone may be depressed.
Anxiety is characterized by persistent worry or fear. Depression tends to be characterized by low mood, feelings of hopelessness, low self-esteem, loss of interest in things that used to be enjoyable, withdrawal from social interaction, and in some cases, thoughts of self-harm or suicide. Anxiety can lead to depression.

Recommendations for use
Pari-Flo recommended as a dietary supplement to the diet:

  • with psychoemotional and psychosomatic disorders caused by stress, vegetative-vascular dystonia, arterial hypertension, hormonal disorders (menopause, premenstrual syndrome, hyperthyroidism, etc.)
  • with depressive conditions
  • with neuroses and neurasthenia of various genesis
  • with increased irritability, states of fear, anxiety, anxiety
  • with migraine attacks
  • with convulsive syndrome against a background of neurological diseases and metabolic disorders

The forced swimming test is one of the most commonly used animal models for investigating the antidepressant-like effects of conventional drugs and herbal substances in mice and rats.

In a study with Imipramine and Pari-Flo, imipramine reduced the immobility times of animals as in other studies. As a tricyclic antidepressant, imipramine increased both swimming and climbing behavior, which may be due to its effect on noradrenergic and serotonergic pathways. Pari-Flo was also found to decrease the immobility time of mice as dose-dependent manner, which indicates an antidepressant-like effect.

Pari-Flo contains–active ingredients:
Passiflora Incarnata L., herba extractum, L-Glycine, L-Methylfolate, Magnesium L-Threonate

L-Methylfolate; is an active component of Pari-Flo; can be highly effective in helping with depression and other mental health issues. It is particularly effective because it can be carried through the blood-brain barrier to aid with neurotransmitters, mood regulation, and other brain functions. Studies have found methylfolate to be most effective with depression when added to an antidepressant regimen.
There are no reported or known side effects of Pari-Flo.

L-Methylfolate plus an antidepressant from the initiation of treatment may result in greater efficacy and more rapid improvement in depressive symptoms compared to standard antidepressant monotherapy.*

*Ginsberg LD, Oubre AY, Daoud YA. L-methylfolate Plus SSRI or SNRI from Treatment Initiation Compared to SSRI or SNRI Monotherapy in a Major Depressive Episode. Innov Clin Neurosci. 2011;8(1):19-28.